Ace the 2026 LECOM OMS-1 Heart Embryology Exam – Beat the Book and Master Cardiac Development!

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Epicardial-derived cells migrate into which tissue to form the coronary vasculature?

Endocardium

Pericardium

Myocardium

Epicardial-derived cells give rise to the coronary vasculature by migrating into the heart muscle itself. After they undergo epithelial-to-mesenchymal transition, they invade the myocardium and differentiate into endothelial and smooth muscle cells that form the coronary vascular network within the myocardial tissue. The endocardium lines the heart chambers, the pericardium is the surrounding sac, and the epicardium is the outer covering they originate from, not the tissue they migrate into to form the coronary vessels.

Epicardium